American Society of Clinical Oncology General Meeting 2022 Wednesday, June 15, 2022 June 3-7, 2022 – McCormick Place, Chicago CCTG MA32 Metformin, placebo, and endocrine therapy discontinuation among participants in a randomized double-blind trial of metformin versus placebo in hormone receptor–positive early-stage breast cancer (CCTG MA32) Session Type: Poster Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 526) Authors: Dawn L. Hershman, Bingshu E. Chen, Wendy R. Parulekar, Julie Lemieux, Jennifer A. Ligibel, Karen A. Gelmon, Timothy Joseph Whelan, Pamela Jean GoodwinAbstract link to be confirmed. Abstract link: https://meetings.asco.org/abstracts-presentations/210746 CCTG MA37 Impact of body mass index on treatment and outcomes in patients with early hormone receptor-positive breast cancer receiving endocrine therapy with or without palbociclib in the PALLAS trial Session Type: Poster Discussion Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 518) Authors: Georg Pfeiler, Dominik Hlauschek, Erica L. Mayer, Christine Deutschmann, Stephanie Kacerovsky-Strobl, Miguel Martin, Jane Lowe Meisel, Nicholas Zdenkowski, Sibylle Loibl, Marija Balic, Haeseong Park, Aleix Prat, Claudine Isaacs, Jana Machacek-Link, Celine Schurmans, Kathy Puyana Theall, Christian Fesl, Amylou C. Dueck, Angela DeMichele, Michael Gnant Abstract link: https://meetings.asco.org/abstracts-presentations/209134 CCTG MAC28 NRG-BR007: A phase III trial evaluating de-escalation of breast radiation (DEBRA) following breast-conserving surgery (BCS) of stage 1, hormone receptor+, HER2-, RS ≤18 breast cancer Session Type: Poster Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS613) Authors: Julia R. White, Stewart J. Anderson, Eleanor Elizabeth Harris, Eleftherios P. Mamounas, Daniel G. Stover, Patricia A. Ganz, Reshma Jagsi, Reena S. Cecchini, Carmen Bergom, Valerie Theberge, Mahmoud El-Tamer, Richard C. Zellars, Dean Alden Shumway, Guang-Pei Chen, Thomas B. Julian, Norman Wolmark Abstract link: https://meetings.asco.org/abstracts-presentations/213519 CCTG MAC22 Adjusting the TMIST study design to accommodate slower than expected accrual: ECOG-ACRIN EA1151 Session Type: Poster Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS10614) Authors: Etta Pisano, Constantine Gatsonis, Mitchell D. Schnall, Martin Yaffe, Melissa A. Troester, Ilana F. Gareen, Laura C. Collins, Amarinthia Curtis, Elodia B Cole, Jean Cormack, Jon Steingrimsson, Ruth C Carlos, Kathy Miller, Christopher Comstock Abstract link: https://meetings.asco.org/abstracts-presentations/213412 CCTG MAC11 Vitamin D insufficiency as a peripheral neuropathy risk factor in white and black patients in SWOG 0221 Session Type: Poster Discussion Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 12023) Authors: Ciao-Sin Chelsea Chen, Gary Zirpoli, Susan McCann, William E. Barlow, George Thomas Budd, Lajos Pusztai, Gabriel N. Hortobagyi, Andrew K. Godwin, Alastair Mark Thompson, Christine B. Ambrosone, Kathleen A Stringer, Daniel Louis Hertz Abstract link: https://meetings.asco.org/abstracts-presentations/209887 CCTG CO26 Effects of liver metastases on efficacy of immune checkpoint blockade in treatment refractory, metastatic colorectal cancer (CRC): CCTG CO.26 Session Type: Poster Session Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3600) Authors: Eric Xueyu Chen, Jonathan M. Loree, Dongsheng Tu, Christopher J. O'Callaghan, Hagen Fritz Kennecke, Derek J. Jonker, Ahmad Chaudhary, Bruce Colwell, Mohammed Harb, Nathalie Aucoin, Felix Couture, Setareh Samimi, Petr Kavan, Francine Aubin, Benoit Samson, John R. Goffin, Scott Berry, Tahir Abbas, Sheryl L. Koski, Alice Chia-chi Wei Abstract link: https://meetings.asco.org/abstracts-presentations/208510 CCTG CO26 Impact of consensus molecular subtyping (CMS) on survival in the CO.26 trial of durvalumab plus tremelimumab versus best supportive care (BSC) in metastatic colorectal cancer (mCRC) Session Type: Poster Session Session Title: Gastrointestinal Cancer – Colorectal and Anal Track: Gastrointestinal Cancer – Colorectal and Anal Citation: https://meetings.asco.org/abstracts-presentations/208452 Authors: Jonathan M. Loree, James T. Topham, Hagen Fritz Kennecke, Harriet Feilotter, Young S Lee, Shakeel Virk, Scott Kopetz, Dzifa Yawa Duose, Ganiraju C. Manyam, Jeffrey S Morris, Dipen M. Maru, Daniel Renouf, Derek J. Jonker, Dongsheng Tu, Christopher J. O'Callaghan, Eric Xueyu Chen Abstract link: https://meetings.asco.org/abstracts-presentations/208452 CCTG CRC5 Gene expression of vitamin D (VitD) pathway markers and survival in patients (Pts) with metastatic colorectal cancer (mCRC): CALGB/SWOG 80405 (Alliance) Session Type: Poster Session Session Title: Gastrointestinal Cancer – Colorectal and Anal Track: Gastrointestinal Cancer – Colorectal and Anal Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3553) Authors: Christine G Kohn, Fang-Shu Ou, Chao Ma, Nicholas B Larson, Tyler J. Zemla, Chen Yuan, Donna Niedzwiecki, Bruce W. Hollis, Andrew B. Nixon, Heinz-Josef Lenz, Charles David Blanke, Richard M. Goldberg, Robert J. Mayer, Alan P. Venook, Eileen Mary O'Reilly, Jeffrey A. Meyerhardt, Kimmie Ng Abstract link: https://meetings.asco.org/abstracts-presentations/208514 CCTG CRC5 Predictive value of MAOB gene expression for targeted therapy in patients (pts) with metastatic colorectal cancer (mCRC) enrolled in CALGB (Alliance)/SWOG 80405 Session Type: Poster Session Session Title: Gastrointestinal Cancer – Colorectal and Anal Track: Gastrointestinal Cancer – Colorectal and Anal Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3580) Authors: Wu Zhang, Joshua Millstein, Yan Yang, Fang-Shu Ou, Federico Innocenti, Hiroyuki Arai, Shivani Soni, Shannon M. Mumenthaler, Sandra Algaze, Priya Jayachandran, Monica M. Bertagnolli, Dustin A. Deming, Donna Niedzwiecki, Richard M. Goldberg, Robert J. Mayer, Charles David Blanke, Alan P. Venook, Omar Kabbarah, Francesca Battaglin, Heinz-Josef Lenz Abstract link: https://meetings.asco.org/abstracts-presentations/208442 CCTG CRC.2 Effect of primary tumor sidedness on the association of tumor-infiltrating lymphocytes with survival of patients with stage III colon cancer (NCCTG N0147) [alliance] Session Type: Poster Session Session Title: Gastrointestinal Cancer – Colorectal and Anal Track: Gastrointestinal Cancer – Colorectal and Anal Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3525) Authors: Bahar Saberzadeh Ardestani, Nathan R. Foster, Hee Eun Lee, Qian Shi, Steven R Alberts, Thomas C. Smyrk, Frank A. Sinicrope Abstract link: https://meetings.asco.org/abstracts-presentations/208355 CCTG PR.21 A randomized phase II study of [177lu]lu-PSMA-617 verus docetaxel in patients with metastatic castration-resistant prostate cancer and PSMA-positive disease (NCT04663997) Session Type: Poster Session Session Title: Genitourinary Cancer – Prostate, Testicular, and Penile Track: Genitourinary Cancer – Prostate, Testicular, and Penile Subtrack: Genitourinary Cancer – Prostate, Testicular, and Penile Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS5110) Authors: Kim N. Chi, Fred Saad, Wendy R. Parulekar, Urban Emmenegger, Sebastien J. Hotte, Frederic Pouliot, Glenn Bauman, Katherine A. Zukotynski, Stuart Peacock, Alexander William Wyatt, Jean-Mathieu Beauregard, Justin Lee, Carlos Uribe, Conor Dellar, Keyue Ding, Francois Benard Abstract link: https://meetings.asco.org/abstracts-presentations/213296 CCTG BL.13 A randomized phase II trial assessing trimodality therapy with or without adjuvant durvalumab to treat patients with muscle-invasive bladder cancer (NCT03768570) Session Type: Poster Session Session Title: Genitourinary Cancer – Kidney and Bladder Track: Genitourinary Cancer – Kidney and Bladder Subtrack: Genitourinary Cancer – Kidney and Bladder Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS4619) Authors: Wassim Kassouf, Simon J. Crabb, Ignacio Duran, Michael Donald Brundage, M. Neil Reaume, Alice Dragomir, Alexander William Wyatt, Francisco Emilio Vera Badillo, Himu Lukka, Tamim Niazi, Luis Souhami, Srikala S. Sridhar, Gareth Owen Griffiths, Doris Howell, Harriet Richardson, Marina Djurfeldt, Keyue Ding, Wendy R. Parulekar Abstract link: https://meetings.asco.org/abstracts-presentations/213450 CCTG BLC.5 MAIN-CAV: Phase III randomized trial of maintenance cabozantinib and avelumab versus avelumab after first-line platinum-based chemotherapy in patients with metastatic urothelial cancer (mUC) (Alliance A032001) Session Type: Poster Session Session Title: Genitourinary Cancer – Kidney and Bladder Track: Genitourinary Cancer – Kidney and Bladder Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS4607) Authors: Shilpa Gupta, Karla V. Ballman, Matt D. Galsky, Michael J. Morris, Ronald C. Chen, Timothy A. Chan, Laurent Dercle, Yujia Wen, Srikala S. Sridhar, Aihua Edward Yen, Petros Grivas, Alan Tan, Shiva Baghaie, Jonathan E. Rosenberg Abstract link: https://meetings.asco.org/abstracts-presentations/213289 BR.34 Effect of bone metastasis on outcomes in the CCTG BR.34 phase II randomized trial of dual immune checkpoint inhibitor (ICI) treatment with or without chemotherapy in high-risk, stage IVA/B NSCLC Session Type: Poster Session Session Title: Lung Cancer – Non-Small Cell Metastatic Track: Lung Cancer Subtrack: Lung Cancer Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9067) Authors: Kim Leitzel, Suhail M. Ali, Keyue Ding, Natasha B. Leighl, Francisco Emilio Vera Badillo, Pierre-Olivier Gaudreau, Penelope Ann Bradbury, Glenwood D. Goss, Lois E. Shepherd, Luis Costa, Larry J Suva, Joseph J. Drabick, Patrick C. Ma, Monika Joshi, Hyma Vani Polimera, Allan Lipton Abstract link: https://meetings.asco.org/abstracts-presentations/212914 CCTG BRC.6 Representativeness of patients enrolled in the Lung Cancer Master Protocol (Lung-MAP) Session Type: Poster Session Session Title: Health Services Research and Quality Improvement Track: Health Services Research and Quality Improvement Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 6543) Authors: Riha Vaidya, Joseph M. Unger, Lu Qian, Katherine Minichiello, Roy S. Herbst, David R. Gandara, Joel W. Neal, Ticiana Leal, Jyoti D. Patel, Konstantin H. Dragnev, Saiama Naheed Waqar, Martin Joseph Edelman, Ellen V. Sigal, Stacey Adam, Shakun M. Malik, Charles David Blanke, Michael Leo LeBlanc, Karen Kelly, Mary Weber Redman Abstract link: https://meetings.asco.org/abstracts-presentations/206721 CCTG BRC.6I Dynamic changes in serum analyte levels associated with clinical outcome in squamous cell lung cancer trial SWOG Lung-MAP S1400I of nivolumab ± ipilimumab Session Type: Poster Session Session Title: Lung Cancer – Non-Small Cell Metastatic Track: Lung Cancer Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9044) Authors: Edgar Gonzalez-Kozlova, Hsin-Hui Huang, Mary Weber Redman, Roy S. Herbst, Scott N. Gettinger, Lyudmila Bazhenova, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, Ethan Cerami, Joyce Hong, Roshni Biswas, Stephen Van Nostrand, Karen Kelly, Radim Moravec, Diane Del Valle, Seunghee Kim-Schulze, Sacha Gnjatic Abstract link: https://meetings.asco.org/abstracts-presentations/209307 CCTG BRC.6I Multiomics profiling and association with molecular and immune features in association with benefits from immunotherapy for patients with previously treated stage IV or recurrent squamous cell lung cancer from the phase III SWOG LungMAP S1400I trial Session Type: Poster Session Session Title: Lung Cancer – Non-Small Cell Metastatic Track: Lung Cancer Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9046) Authors: Edwin R. Parra, Dzifa Yawa Duose, Jiexin Zhang, Mary Weber Redman, Rossana Lazcano Segura, Mario L. Marques-Piubelli, Caddie Laberiano Fernandez, BaiLi Zhang, James Lindsay, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Roy S. Herbst, Ignacio Ivan Wistuba, Scott N. Gettinger, Lyudmila Bazhenova, J. Jack Lee, Jianjun Zhang, Cara L. Haymaker Abstract link: https://meetings.asco.org/abstracts-presentations/212896
