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CCTG at ASCO 2026

CCTG at ASCO 2026

The 2026 #ASCO Annual Meeting will be held in Chicago this weekend from May 29 through June 2 with a range of abstracts from CCTG trials. Here is a list of the research that will be presented with abstract links - if you are attending make sure to stop by!

BREAST

CCTG MAC.30/NRG BR009 
A phase III trial evaluating addition of adjuvant chemotherapy to ovarian function suppression + endocrine therapy in premenopausal women with pN0-1, HR+/HER2- breast cancer (BC) and oncotype recurrence score (RS) ≤25 (OFSET): NRG-BR009.
Abstract:TPS650 Session Type: Poster Session Session Title:Breast Cancer—Local/Regional/Adjuvant
Citation: J Clin Oncol 44, 2026 (suppl 16; abstr TPS650)    
Authors:     Eleftherios Mamounas, Gong Tang, Shannon Puhalla, Sandra Swain, Patricia Ganz, Norah Henry, Reena Cecchini,      Sonya Reid, Priya Rastogi, Charles Geyer Jr., Julia White, Amy Clark, Tufia Haddad, Gregory Vidal, Norman Wolmark
Abstract link: https://www.asco.org/abstracts-presentations/266595

GASTROINTESTINAL

CCTG CO.21
Structured exercise program following adjuvant chemotherapy for colon cancer: A cost-utility analysis of the CHALLENGE trial
Abstract #:    3507 Session Type: Oral Abstract Session  Session Title: Gastrointestinal Cancer—Colorectal and Anal
Track:    Gastrointestinal Cancer—Colorectal and Anal
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr 3507)
Authors:     Kelvin K. Chan, Ryan W. Chu, Matthew C. Cheung, Kerry S. Courneya, Christopher J. O'Callaghan, Janette L. Vardy. Sharlene Gill, Christine Friedenreich, Rebecca K. Wong, Haryana M. Dhillon, Vicky Coyle, Neil S. Chua, Derek J. Jonker, Ralph M. Meyer, Shahid Ahmed, John R. Zalcberg, Stephen J. Clarke, Patti O'Brien, Dongsheng Tu, Christopher M. Booth
Abstract link:   https://www.asco.org/abstracts-presentations/260675

CCTG CO.33
The CO.33/BATTMAN trial: A phase 3 randomized study of botensilimab + balstilimab versus best supportive care in chemorefractory unresectable colorectal adenocarcinoma that is not dMMR/MSI-H.
Abstract #: TPS3676 Session Type: Poster Session Session Title:Gastrointestinal Cancer—Colorectal and Anal
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr TPS3676) 
Authors:     Jonathan M. Loree, Jeanne Tie, Emmanuelle Samalin, Sharlene Gill, Benny Johnson, Joseph E. Grossman, Steven O'Day, Eric X. Chen, Christos S. Karapetis, Christelle De La Fouchardiere, Winson Y. Cheung, Kelvin K. Chan, Catherine Rutledge, Dongsheng Tu, Christopher J. O'Callaghan
Abstract link:   https://www.asco.org/abstracts-presentations/266856

CCTG CO.26
Serum VEGF-A concentrations as a predictive biomarker of immunotherapy response in refractory metastatic colorectal cancer (mCRC): An exploratory analysis of CCTG CO.26
Abstract #:    3547 Session Type:     Poster Session Session Title:     Gastrointestinal Cancer—Colorectal and Anal
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr 3547)
Authors:     François Jobin Gervais, Xin Wang, Jonathan M. Loree, Emma Titmuss, Trevor J. Pugh, Derek J. Jonker, Hagen F. Kennecke, Scott Berry, Aaron R. Hansen, Philippe Bedard, Stephanie Lheureux, Anna Spreafico, Albiruni R. Abdul Razak, Lillian L. Siu, Felix Couture, Ahmad Chaudhary, John R. Goffin, Dongsheng Tu, Christopher J. O'Callaghan, Eric X. Chen
Abstract link:   https://www.asco.org/abstracts-presentations/262550

CCTG CRC.6/CALGB/SWOG 80702
Lycopene and survival in patients with stage III colon cancer: Findings from CALGB (Alliance)/SWOG 80702
Abstract #:    3630 Session Type:     Poster Session Session Title:     Gastrointestinal Cancer—Colorectal and Anal 
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr 3630)
Authors:     Seohyuk Lee, Qian Shi, Chao Ma, Pankaj Kumar, Felix Couture, J. P. Kuebler, Smitha S. Krishnamurthi, Benjamin R. Tan, Eileen M. O'Reilly, Anthony F. Shields, Edward L. Giovannucci, Yasmin Mossavar-Rahmani, Jeffrey A. Meyerhardt, En Cheng
Abstract link:  https://www.asco.org/abstracts-presentations/262239

CCTG CRC.10/NRG GI008
Colon adjuvant chemotherapy based on evaluation of residual disease (CIRCULATE-NORTH AMERICA): NRG-GI008.
Abstract #:    TPS3686
Session Type:     Poster Session
Session Title:     Gastrointestinal Cancer—Colorectal and Anal
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr TPS3686)    
Authors:     Arvind Dasari, Guan Yu, Scott Kopetz, Shannon Puhalla, Peter Lucas, Ibrahim Halil Sahin, Dustin Deming, Philip Philip, Theodore Hong, Yesenia Rojas-Khalil, Jonathan Loree, Norman Wolmark, Greg Yothers, Thomas George, Christopher Lieu
Abstract link:  https://www.asco.org/abstracts-presentations/266852


GENITOURINARY 

CCTG GCC1/SWOG S1823
First interim analysis of SWOG S1823: Operating characteristics of circulating microRNA 371a-3p (miR371) in predicting active germ cell malignancy (aGCM) in patients (pts) with early-stage testicular cancer.
Abstract #:    LBA5003 Session Type:     Oral Abstract Session Session Title:     Genitourinary Cancer—Prostate, Testicular, and Penile
Citation:    J Clin Oncol 44, 2026 (suppl 17; abstr LBA5003)    
Authors:     Lucia Nappi, Sarah Colby, Robert W. Hamilton, Andrea Harzstark, Nabil Adra, Siamak Daneshmand, Christopher W. Ryan, Scott E. Eggener, Chunkit Fung, Rebecca Johnson, Seth P. Lerner, Kathryn B. Arnold, Banu Arun, James M. Rae, Charles D. Blanke, Michael LeBlanc, Wendy R. Parulekar, Lawrence H. Einhorn, Christian K. Kollmannsberger, Craig R. Nichols
Abstract link:  https://www.asco.org/abstracts-presentations/260571

 

CCTG PR.21
Canadian Cancer Trials Group (CCTG) study PR21 (PLUDO): Results of crossover treatment from a randomized trial of 177Lu-PSMA-617 (LuP) vs docetaxel (DOC) in patients with metastatic castration-resistant prostate cancer (mCRPC).
Abstract #:    5019 Session Type:     Rapid Oral Abstract Session Session Title:     Genitourinary Cancer—Prostate, Testicular, and Penile
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr 5019)    
Authors:     Kim N. Chi, Fred Saad, Keyue Ding, Glenn Bauman, Urban Emmenegger, Sebastien J. Hotte, Frederic Pouliot, Justin Lee, Jean-Mathieu Beauregard, Lucia Nappi, Christian K. Kollmannsberger, Zineb Hamilou, Gad Abikhzer, Michel Pavic, Scott A. North, Di Maria Jiang, Steven Yip, Conor Dellar, Wendy R. Parulekar, Francois Benard
Abstract link:  https://www.asco.org/abstracts-presentations/258188/abstract

CCTG PR25
A randomized phase III trial investigating platinum and taxane chemotherapy in metastatic castration-resistant prostate cancer (mCRPC) patients with alterations in DNA damage response (DDR) genes (OPTION-DDR) CCTG-PR-25 NCT06439225.
Abstract #:    TPS5143
Session Type:     Poster Session
Session Title:     Genitourinary Cancer—Prostate, Testicular, and Penile
Track:    Genitourinary Cancer—Prostate, Testicular, and Penile    
Citation:    J Clin Oncol 44, 2026 (suppl 16; abstr TPS5143)
Authors:     Michael Ong, Michael P. Kolinsky, Kim N. Chi, Sebastien J. Hotte, Michael D. Brundage, Daniel J. Khalaf, David Boren, M. N. Reaume, Alexander W. Wyatt, Wendy R. Parulekar, Keyue Ding, Mariam Jafri
Abstract link:  https://www.asco.org/abstracts-presentations/266929


CCTG PR.26
TRIPLE-SWITCH (SWOG/CCTG-PR26): A randomized phase III clinical trial for the addition of docetaxel to androgen receptor pathway inhibitors in patients with metastatic castration sensitive prostate cancer (mCSPC) and suboptimal PSA response (NCT06592924).
Abstract #:    TPS5129
Session Type:     Poster Session
Session Title:     Genitourinary Cancer—Prostate, Testicular, and Penile
Track:    Genitourinary Cancer—Prostate, Testicular, and Penile
Citiation:    J Clin Oncol 44, 2026 (suppl 16; abstr TPS5149)
Authors:     Michael Ong, Alexandra Sokolova, Sebastien Hotte, Tanya Dorff, Kim Chi, Alexander Wyatt, Amir Goldkorn, Michael Kolinsky, Michael Brundage, Akunne Ndika, Seth Lerner, Wendy Parulekar, Keyue Ding, Mariam Jafri
Abstract link:  https://www.asco.org/abstracts-presentations/266930

CCTG PRC.4/Alliance A031201
Circulating tumor DNA–based clinical-genetic (CG) prognostic model for radiographic progression-free survival (rPFS) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Analysis of Alliance A031201.
Abstract #:    5018 Session Type:     Rapid Oral Abstract Session Session Title:     Genitourinary Cancer—Prostate, Testicular, and Penile
Citiation:    J Clin Oncol 44, 2026 (suppl 16; abstr 5018)
Abstract link:  https://www.asco.org/abstracts-presentations/259369

 

CCTG REC.4/EA8143

Relationships between clinical stage, pathological stage, and disease-free (DFS) survival in renal cell carcinoma as used to inform future neoadjuvant study design: ECOG-ACRIN EA8143 PROSPER analysis.

Abstract #:        4540 Session Type:  Poster Session Session Title:  Genitourinary Cancer—Kidney and Bladder

Citiation:           J Clin Oncol 44, 2026 (suppl 16; abstr 4540)

Authors:            James O. Jones, Se E. Kim, Mohamad E. Allaf, Viraj A. Master, David F. McDermott, Sabina Signoretti, Axel Bex, Grant D. Stewart, James Blackmur, Nirmish Singla, Nabil Adra, Stephanie A. Berg, Dror Michaelson, Daniel Y. Heng, Brian M. Shuch, Yasser Ged, Mehmet A. Bilen, Gennady Bratslavsky, Michael A. Carducci, Naomi B. Haas

Abstract link:  https://www.asco.org/abstracts-presentations/262634

 

GYNECOLOGIC CANCER

 

CCTG ENC.1/NRG-GY018

Updated overall survival analysis and examination of subsequent therapy in endometrial cancer (EC) patients (pts) treated with pembrolizumab plus carboplatin/paclitaxel (CP) as compared to CP plus placebo (PBO) in the NRG-GY018 trial).

Abstract #:        5502 Session Type:  Oral Abstract Session Session Title:  Gynecologic Cancer

Citation:            J Clin Oncol 44, 2026 (suppl 16; abstr 5502)

Authors:            Ramez N. Eskander, Michael Sill, Lindsey Beffa, Richard G. Moore, Joanie M. Hope, Fernanda Musa, Robert S. Mannel, Mark S. Shahin, Guilherme H. Cantuaria, Eugenia Girda, Cara A. Mathews, Juraj Kavecansky, Charles A. Leath III, Lilian T. Gien, Emily Hinchcliff, Shashikant B. Lele, Lisa M. Landrum, Floor J. Backes, Matthew A. Powell, Carol Aghajanian

Abstract link:  https://www.asco.org/abstracts-presentations/258036

 

HEAD AND NECK CANCER

 

CCTG HN.9

Final analysis of the investigator-initiated randomized study of anti–PD-L1 durvalumab (durva) with radiation versus chemoradiation (CRT) for intermediate-risk HPV-positive (HPV+) locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC): Canadian Cancer Trials Group (CCTG) HN.9 (EORTC 1740-HNCG).

Abstract #:        6017

Session Type:  Rapid Oral Abstract Session

Session Title:  Head and Neck Cancer

Citation:            J Clin Oncol 44, 2026 (suppl 16; abstr 6017)             

Authors:            Anna Spreafico, Khalil Sultanem, Jean-Pascal H. Machiels, Scott V. Bratman, John Hilton, Lisa F. Licitra, Alexander V. Louie, Andrea McNiven, Jolie Ringash, Lillian L. Siu, John Waldron, Osama Souied, Andrew G. Robinson, Changshu Wang, Craig H. Harlos, Marc Oliva, John W. Walker, Kate Whelan, Wei Tu, Wendy R. Parulekar

Abstract link:  https://www.asco.org/abstracts-presentations/260979    

 

LUNG/THORACIC ONCOLOGY

 

CCTG BR.34

Effect of dual immune checkpoint inhibitors (ICI) by the time of infusion in advanced non–small cell lung cancer (NSCLC): A secondary analysis of CCTG BR34 trial

Abstract #:        8566

Session Type:  Poster Session

Session Title:  Lung Cancer – Non-Small Cell Metastatic

Track:                  Lung Cancer

Citation:            J Clin Oncol 44, 2026 (suppl 16; abstr 8566)

Authors:            Sze Wah Samuel Chan, Adi Kartolo, Keyue Ding, Pierre-Olivier Gaudreau, Rosalyn A. Juergens, Natasha B. Leighl, Janet E. Dancey

Abstract link: https://www.asco.org/abstracts-presentations/265945     

 

CCTG BR.38

CCTG BR.38: Consolidative use of radiotherapy to block (CURB2) oligoprogression in patients with metastatic non–small-cell lung cancer—A randomized phase III trial.

Abstract #:        TPS81248566

Session Type:  Poster Session

Session Title:  Lung Cancer—Non–Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Track:                  Lung Cancer

Citation:            J Clin Oncol 44, 2026 (suppl 16; abstr TPS8124)

Authors:            Chiaojung Jillian Tsai, Alexander Sun, Penelope A. Bradbury, Devin Schellenberg, Houda Bahig, Andrea S. Fung, Jean-Pierre Bissonnette, Jeeban Paul Das, Biniam Kidane, Alexander V. Louie, Joseph Miccio, Meng X. Welliver, John M. Varlotto, Arya Amini, Ryan Kelly, Keyue Ding, Pierre-Olivier Gaudreau

Abstract link: https://www.asco.org/abstracts-presentations/266720