Now Implemented in RIPPLE Wednesday, July 18, 2018 The DTL has now been implemented by the Clinical Trials Evaluation Program (CTEP) for selected trials. The first National Clinical Trials Network Trial (NCTN) where CCTG is using the DTL is the BLC.4 trial. An active DTL is now a requirement for CCTG sites following approval of the BLC.4 Revision #3. Other upcoming studies that will be using the DTL initially include MAC.24 and REC.4. Canadian sites will complete the DTL directly in the CCTG Roster Interface Program and Participants List Environment (RIPPLE) and are required to complete both components of the trial participants list in RIPPLE (the CCTG and the NCI US DTL). The integration of the DTL into RIPPLE was implemented on July 16, 2018 and is now available for participating BLC.4 sites. Educational materials (including a RIPPLE Trial Participants DTL Components User Guide and flow diagrams for key actions) are posted on the RIPPLE website. If you have any questions please contact ripple@ctg.queensu.ca.