Wednesday, April 15, 2026 In the CCTG CO.32 NEO-RT (NCT06205485) randomized phase III, patients were treated with either induction chemotherapy or chemoradiotherapy, followed by minimally invasive surgery, with the goal of maximizing organ preservation and function. Kennecke HF, Brown CJ, Whiteford MH, Nurkin, Steven, Cann CG, VanderWalde NA, Cohen SA, Loree JM, Hall WA, Dennis K, Horowitz DP, Locke GE, Kachnic LA, O'Callaghan, Chris J. NEO-RT Organ Preservation Trial for Early Rectal Cancer: CCTG CO.32 Phase III Randomized Trial of Neoadjuvant Chemotherapy, Excision and Observation Versus Chemoradiotherapy JCO Oncology Advances 3: e2500176. 2026. https://ascopubs.org/doi/abs/10.1200/OA-25-00176
