Wednesday, December 17, 2025 A new correlative study from CO.28 has been published: Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay There is increasing interest in organ preservation for early-stage rectal cancer. Circulating tumor DNA (ctDNA) for detection of molecular residual disease may aid in clinical decision making for these approaches.https://ascopubs.org/doi/10.1200/OA-25-00055