Wednesday, November 04, 2026 Drug-related UVA-induced photoreactions have been reported for several therapeutic compounds, including fluoroquinolones. CX-5461 is a clinical stage quinolone-derived anti-cancer small molecule with documented UVA-sensitizing activity. Researchers compared, by bulk and clonal whole-genome sequencing under extraneous light-protected conditions, the mutational signatures in human retinal pigment epithelial cells (RPE1) exposed to UVA, CX-5461, or co-exposed to UVA and CX-5461. Zaikova E, Yap D, Sarvar A, Hafezi A, Tan J, Cerda V, Li K, Lai D, Gelmon K, Hilton J, Seymour L, Stirling P, Cescon DW, Aparicio S. The UVA-induced single-base mutational signature of CX-5461 in human cells. Nucleic Acids Research 54: gkag836. 2026.https://doi.org/10.1093/nar/gkag836
