Evaluating the Indirect Costs of Care Associated with Salvage Chemotherapy for Relapsed and Refractory Aggressive-Histology Lymphoma Wednesday, March 31, 2021 Evaluating the Indirect Costs of Care Associated with Salvage Chemotherapy for Relapsed and Refractory Aggressive-Histology Lymphoma: A Subset Analysis of the Canadian Cancer Trials Group (CCTG) LY12 Clinical Trial" has been published in Current Oncology and is available online: https://www.mdpi.com/1718-7729/28/2/119 Researchers conducted an analysis of indirect costs alongside the LY.12 randomized trial in patients with relapsed or refractory (R/R) aggressive non-Hodgkin lymphoma (NHL). Lost productivity data for Canadian patients and caregivers in the trial were collected at baseline and with each chemotherapy cycle pre-transplant, using an adapted Lost Productivity questionnaire. Mean per patient indirect costs were CAD 2999 for patients in the GDP arm and CAD 3400 in the DHAP arm. A substantial majority was not working or had to reduce their workload during this treatment time. Salvage chemotherapy for R/R aggressive NHL is associated with significant indirect costs to patients and their caregivers. Conclusions Salvage chemotherapy for R/R aggressive NHL is associated with substantial indirect costs to the patients and their caregivers, with a large majority not working or having to reduce their workload during this treatment time. Although there were no significant differences in all indirect costs between the two treatment arms, the paid and unpaid care giving costs did appear higher with the DHAP arm. These data potentially provide further support to GDP being the preferred treatment approach in this patient population and interventions to financially support patients and families through this time are warranted.
