Wednesday, November 04, 2026 Establishment of harmonized international reference ranges for plasma estradiol concentrations in postmenopausal womenPrior reports of plasma estradiol concentrations and their reference ranges in postmenopausal women identified marked variation, in part due to assay method and body mass index (BMI). The objective is to develop an international reference range for plasma estradiol in postmenopausal women, support accurate assessment of concentrations during systemic and local (eg, vaginal) estradiol therapy, and improve risk prediction for diseases, including osteoporosis, breast, and endometrial cancers.Cui J, Hankinson SE, Matsumoto AM, Santen RJ, Boutot ME, Budd JR, Dowsett M, Goetz MP, Guranich C, Houghton S, Ingle JN, Jones ME, Rinaldi S, Rosner B, Schoemaker MJ, Singh RJ, Vesper HW, Eliassen AH, Milne RL, Swerdlow AJ, Vachon CM, Richardson H, Qian J. Establishment of harmonized international reference ranges for plasma estradiol concentrations in postmenopausal women. The Journal of Clinical Endocrinology & Metabolism 111: 2745-2755. 2026. https://doi.org/10.1210/clinem/dgag188
