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Publication: Statistical

Publication: Statistical
Joint Analysis of Longitudinal Proportional Measurements and Survival Times Based on Generalized Mean-Variance Mixed Model and Cox Proportional Hazards Model
 
In cancer clinical trials and other types of medical studies, longitudinal data are often observed in conjunction with survival data. For example, data on relapse-free survival, defined as time from randomization to cancer recurrence, were collected in a clinical trial conducted by the Canadian Cancer Trials Group (CCTG) to compare the efficacy of an intensive chemotherapy treatment combination CEF against the standard treatment CMF in pre-menopausal women with early breast cancer (Levine et al. 2005).
 
Wang Z, Jiang S, Xiao L, Tu D. Joint Analysis of Longitudinal Proportional Measurements and Survival Times Based on Generalized Mean-Variance Mixed Model and Cox Proportional Hazards Model. Stat 14: e70092. 2025.