Wednesday, May 08, 2024 The BLC5 (Alliance A032001): MAIN-CAV: Phase III Randomized Trials of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum Based Chemotherapy in Patients with Metastatic Urothelial Cancer Trial has permanently closed. Study results have not yet been provided by the lead group to www.clinicaltrials.gov This phase III trial compared the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib and avelumab together may further shrink the cancer or prevent it from returning/progressing. Metastatic urothelial cancer is an incurable disease with a limited life expectancy. This study builds on the Javelin Bladder 100 trial which established the current standard of care that consists of platinum-based chemotherapy followed by maintenance immunotherapy in combination with an immunotherapy drug. For more information please visit the CCTG BLC5 members trial page.
