CCTG has opened the anticipated international brain cancer study CCTG CE9 (LUMOS2) - joining forces with the Australian Cooperative Trials Group for Neuro-Oncology (COGNO) to make enrollment accessible to Canadian patients.
Novel Therapeutics in Younger Patients with High-Risk AML (MM1YA-S01)
MODERN: An Integrated Phase 2/3 and Phase 3 Trial of MRD-Based Optimization of Adjuvant Therapy in Urothelial Cancer
Comparing Palliative Stereotactic Body Radiotherapy vs. Palliative Standard Radiotherapy in Patients with Advanced Head and Neck Cancer
LND101 for Fecal Microbiota Transplantation in Combination with Immune Checkpoint Blockade in Patients with Advanced Melanoma
The CCTG ES3 NEEDS international esophageal cancer clinical trial is now opened in Canada. The study is investigating whether delaying surgery for patients with squamous cell carcinoma of the esophagus is as good as the current treatment.
Eradicating MRD in Patients with AML prior to Stem Cell Transplant (ERASE)
Radiotherapy to Block (CURB2) Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
VIGOR: Vorasidenib as Maintenance Treatment after First-line Chemoradiotherapy in IDH-mutant Grade 2 or 3 Astrocytoma
Botensilimab + Balstilimab or Botensilimab Alone vs Best Supportive Care as Therapy in Chemo-refractory, Advanced, Colorectal Adenocarcinoma: The BATTMAN Trial
STRIDE (durvalumab + tremelimumab) with Lenvatinib vs STRIDE Alone in Patients with Unresectable Hepatocellular Carcinoma (SLIDE-HCC)
CALMS: Combination Therapy with Luspatercept in Lower Risk MDS CTEP approval: 2024AUG27 (date of US Steering Committee Evaluation)
The new BLC6 MODERN phase II/III clinical trial will investigate the role of circulating tumour DNA (ctDNA) in the blood to see if it is an effective guide for what type of immunotherapy is most effective. Researchers want to understand whether a blood test can more effectively determine who should get immunotherapy after surgery for bladder cancer and which immunotherapy treatment is best.
In early November, our CCTG Patient Representative Committee Chair, Judy Needham was invited to Brussels, Belgium, as a Breast International Group (BIG) Patient Partner. During her visit she attended BIG Executive Board Meetings, Patient Partner Meetings, and was privileged to be invited to a luncheon with the Queen Mathilde of Belgium who is the honorary President of BIG.
With sadness CCTG acknowledges the passing of one of our influential international research partners, Mr Russell Conley. Russell was Chief Executive Officer of the Australasian Gastro-Intestinal Trials Group (AGITG) and the GI Cancer Institute for 22 years. He was instrumental in all of the growing list of CCTG and AGITG GI collaborations, including CO.17, CO.20, CO.23, CO.29, NE.2 as well as the Commonwealth Neuroendocrine Tumour Research Collaboration (CommNETs).
The recently opened CCTG PR25 clinical trial uses a personalized medicine approach to investigate and evaluate markers to determine which metastatic prostate cancer patients would benefit from treatment with carboplatin a drug used in other cancers but not routinely used in prostate cancer.
